BRINP3

BMP/retinoic acid inducible neural specific 3 is a protein that in humans is encoded by the BRINP3 gene. ^[5]

BRINP3
Identifiers
Aliases	BRINP3, DBCCR1L, DBCCR1L1, FAM5C, BMP/retinoic acid inducible neural specific 3
External IDs	OMIM: 618390; MGI: 2443035; HomoloGene: 17786; GeneCards: BRINP3; OMA:BRINP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.1 Start 190,097,658 bp[1] End 190,478,404 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 F|1 63.24 cM Start 146,370,498 bp[2] End 146,778,210 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle endothelial cell prefrontal cortex primary visual cortex right frontal lobe amygdala dorsolateral prefrontal cortex cingulate gyrus Brodmann area 9 Top expressed in lumbar subsegment of spinal cord ventromedial nucleus mammillary body anterior amygdaloid area piriform cortex dorsomedial hypothalamic nucleus supraoptic nucleus lateral hypothalamus suprachiasmatic nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 339479 215378 Ensembl ENSG00000162670 ENSMUSG00000035131 UniProt Q76B58 Q499E0 RefSeq (mRNA) NM_199051 NM_001317188 NM_001145807 NM_153539 NM_001357571 NM_001357572 RefSeq (protein) NP_001304117 NP_950252 NP_001139279 NP_705767 NP_001344500 NP_001344501 Location (UCSC) Chr 1: 190.1 – 190.48 Mb Chr 1: 146.37 – 146.78 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].