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BRMS1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

BRMS1
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Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[5][6]

Quick Facts Available structures, PDB ...

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[7] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[6]

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