BRSK1

BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene.^[5]

BRSK1
Identifiers
Aliases	BRSK1, hSAD1, BR serine/threonine kinase 1, SAD-B
External IDs	OMIM: 609235; MGI: 2685946; HomoloGene: 57169; GeneCards: BRSK1; OMA:BRSK1 - orthologs
EC number	2.7.11.26
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,282,072 bp[1] End 55,312,562 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,693,603 bp[2] End 4,718,996 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe Brodmann area 9 right hemisphere of cerebellum prefrontal cortex cingulate gyrus anterior cingulate cortex ganglionic eminence amygdala hypothalamus putamen Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell prefrontal cortex central gray substance of midbrain cerebellar cortex nucleus of stria terminalis hippocampus proper cingulate gyrus piriform cortex More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding kinase activity protein kinase binding magnesium ion binding protein serine/threonine kinase activity ATP binding tau-protein kinase activity gamma-tubulin binding tau protein binding Cellular component synapse nucleoplasm microtubule organizing center cytoskeleton cell junction cytoplasm synaptic vesicle centrosome nucleus presynaptic active zone distal axon Biological process response to ionizing radiation neuron projection morphogenesis intracellular signal transduction phosphorylation nervous system development cell cycle response to UV cellular response to DNA damage stimulus centrosome duplication establishment of cell polarity neurotransmitter secretion axonogenesis neuron differentiation protein phosphorylation mitotic G2 DNA damage checkpoint signaling associative learning regulation of neuron projection development regulation of synaptic plasticity regulation of axonogenesis microtubule cytoskeleton organization involved in establishment of planar polarity synaptic vesicle cycle regulation of synaptic vesicle clustering Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84446 381979 Ensembl ENSG00000160469 ENSMUSG00000035390 UniProt Q8TDC3 Q5RJI5 RefSeq (mRNA) NM_032430 NM_001003920 NM_001168572 RefSeq (protein) NP_115806 NP_001003920 NP_001162044 Location (UCSC) Chr 19: 55.28 – 55.31 Mb Chr 7: 4.69 – 4.72 Mb PubMed search [3] [4]
Wikidata
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