BRSK2

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.^[5][6][7]

BRSK2
Identifiers
Aliases	BRSK2, C11orf7, PEN11B, SAD1, SADA, STK29, BR serine/threonine kinase 2, SAD-A
External IDs	OMIM: 609236; MGI: 1923020; HomoloGene: 123829; GeneCards: BRSK2; OMA:BRSK2 - orthologs
EC number	2.7.11.26
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 1,389,899 bp[1] End 1,462,689 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,503,488 bp[2] End 141,557,984 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum body of pancreas right frontal lobe ganglionic eminence anterior cingulate cortex Brodmann area 9 prefrontal cortex C1 segment nucleus accumbens amygdala Top expressed in visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell neural layer of retina cerebellar cortex prefrontal cortex hippocampus proper ganglionic eminence lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity ATPase binding ATPase regulator activity metal ion binding kinase activity protein kinase binding magnesium ion binding tau-protein kinase activity protein serine/threonine kinase activity ATP binding tau protein binding Cellular component centrosome microtubule organizing center perinuclear region of cytoplasm cytoskeleton nucleus cytoplasm endoplasmic reticulum distal axon Biological process actin cytoskeleton reorganization neuron projection morphogenesis ERAD pathway phosphorylation nervous system development cell division intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress G2/M transition of mitotic cell cycle peptidyl-serine phosphorylation cell cycle regulation of ATP-dependent activity regulation of retrograde protein transport, ER to cytosol exocytosis apoptotic process establishment of cell polarity regulation of insulin secretion involved in cellular response to glucose stimulus axonogenesis protein phosphorylation neuron differentiation regulation of neuron projection development intracellular signal transduction regulation of axonogenesis microtubule cytoskeleton organization involved in establishment of planar polarity regulation of synaptic vesicle clustering Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9024 75770 Ensembl ENSG00000174672 ENSMUSG00000053046 UniProt Q8IWQ3 Q69Z98 RefSeq (mRNA) NM_001256627 NM_001256629 NM_001256630 NM_001282218 NM_003957 NM_001009929 NM_001009930 NM_001276763 NM_029426 RefSeq (protein) NP_001243556 NP_001243558 NP_001243559 NP_001269147 NP_003948 NP_001009929 NP_001009930 NP_001263692 NP_083702 Location (UCSC) Chr 11: 1.39 – 1.46 Mb Chr 7: 141.5 – 141.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse