BTAF1

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.^[5][6][7]

BTAF1
Identifiers
Aliases	BTAF1, MOT1, TAF(II)170, TAF172, TAFII170, B-TFIID TATA-box binding protein associated factor 1
External IDs	OMIM: 605191; MGI: 2147538; HomoloGene: 31978; GeneCards: BTAF1; OMA:BTAF1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.32 Start 91,923,770 bp[1] End 92,030,325 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 36,903,479 bp[2] End 36,990,152 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell germinal epithelium hair follicle Achilles tendon cartilage tissue epithelium of nasopharynx pancreatic epithelial cell gastric mucosa tibia skin of arm Top expressed in hand seminiferous tubule condyle spermatocyte fossa medullary collecting duct primitive streak epidermis abdominal wall hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding nucleotide binding hydrolase activity ATP binding helicase activity protein binding Cellular component intracellular membrane-bounded organelle nucleus nucleoplasm Biological process negative regulation of transcription, DNA-templated negative regulation of chromatin binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9044 107182 Ensembl ENSG00000095564 ENSMUSG00000040565 UniProt O14981 Q2M1V9 E9QAE3 RefSeq (mRNA) NM_003972 NM_001080706 RefSeq (protein) NP_003963 NP_003963.1 NP_001074175 Location (UCSC) Chr 10: 91.92 – 92.03 Mb Chr 19: 36.9 – 36.99 Mb PubMed search [3] [4]
Wikidata
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Function

Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM]^[7]

Interactions

BTAF1 has been shown to interact with TATA binding protein.^[6][8]