BTNL2

Butyrophilin-like protein 2 is a protein that in humans is encoded by the BTNL2 gene.^[5][6][7]

BTNL2
Identifiers
Aliases	BTNL2, BTL-II, BTN7, HSBLMHC1, SS2, butyrophilin like 2
External IDs	OMIM: 606000; MGI: 1859549; HomoloGene: 10482; GeneCards: BTNL2; OMA:BTNL2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,393,339 bp[1] End 32,407,181 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,573,796 bp[2] End 34,588,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone gonad ganglionic eminence right ovary lymph node left ovary superior frontal gyrus smooth muscle tissue endometrium Top expressed in jejunum duodenum granulocyte morula ileum epithelium of small intestine colon stomach thymus esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding Cellular component membrane integral component of membrane plasma membrane external side of plasma membrane Biological process regulation of immune response T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56244 547431 Ensembl ENSG00000225845 ENSG00000229741 ENSG00000226127 ENSG00000224770 ENSG00000225412 ENSG00000224242 ENSG00000229597 ENSG00000204290 ENSG00000275798 ENSMUSG00000024340 UniProt Q9UIR0 O70355 RefSeq (mRNA) NM_001304561 NM_019602 NM_079835 RefSeq (protein) NP_001291490 NP_524574 Location (UCSC) Chr 6: 32.39 – 32.41 Mb Chr 17: 34.57 – 34.59 Mb PubMed search [3] [4]
Wikidata
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Because it is associated with the immune system and the major histocompatibility complex, it has been implicated in many diseases (see further reading list below). A large scale study found it to be the protein under the most stringent selection in the human genome in 8 out of 12 geographic regions using the HKA test.^[8]