B cell scaffold protein with ankyrin repeats 1

B cell scaffold protein with ankyrin repeats 1 is a protein that in humans is encoded by the BANK1 gene. ^[5]

BANK1
Identifiers
Aliases	BANK1, BANK, B-cell scaffold protein with ankyrin repeats 1, B cell scaffold protein with ankyrin repeats 1
External IDs	OMIM: 610292; MGI: 2442120; HomoloGene: 9926; GeneCards: BANK1; OMA:BANK1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 101,411,286 bp[1] End 102,074,812 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 63.04 cM Start 135,759,124 bp[2] End 136,031,827 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen appendix epithelium of nasopharynx superficial temporal artery testicle buccal mucosa cell granulocyte blood tonsil Top expressed in mesenteric lymph nodes spleen lumbar spinal ganglion blood subcutaneous adipose tissue zygote secondary oocyte granulocyte Paneth cell submandibular gland More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 55024 242248 Ensembl ENSG00000153064 ENSMUSG00000037922 UniProt Q8NDB2 Q80VH0 RefSeq (mRNA) NM_017935 NM_001083907 NM_001127507 NM_001033350 NM_001310749 RefSeq (protein) NP_001077376 NP_001120979 NP_060405 NP_001028522 NP_001297678 Location (UCSC) Chr 4: 101.41 – 102.07 Mb Chr 3: 135.76 – 136.03 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].