Barrier to autointegration factor 1

Barrier-to-autointegration factor is a protein that in humans is encoded by the BANF1 gene.^[5][6] It is a member of the barrier-to-autointegration factor family of proteins.

BANF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QCK, 2ODG, 1CI4, 2BZF, 2EZY, 2EZZ, 2EZX
Identifiers
Aliases	BANF1, BAF, BCRP1, D14S1460, NGPS, Barrier to autointegration factor 1, BAF nuclear assembly factor 1
External IDs	OMIM: 603811; MGI: 1346330; HomoloGene: 2866; GeneCards: BANF1; OMA:BANF1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 66,002,228 bp[1] End 66,004,149 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,414,666 bp[2] End 5,417,196 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right uterine tube muscle of thigh apex of heart gastrocnemius muscle ascending aorta body of uterus Descending thoracic aorta right coronary artery Top expressed in somite embryo medial ganglionic eminence mandibular prominence maxillary prominence epiblast embryo thymus fetal liver hematopoietic progenitor cell hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding protein C-terminus binding enzyme binding protein homodimerization activity protein N-terminus binding LEM domain binding identical protein binding Cellular component cytoplasm extracellular exosome condensed chromosome nucleus chromosome nucleoplasm cytosol nuclear envelope Biological process mitotic nuclear membrane reassembly response to virus mitotic nuclear membrane disassembly DNA integration establishment of integrated proviral latency viral process nuclear transport negative regulation of viral genome replication chromosome segregation chromosome condensation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8815 23825 Ensembl ENSG00000175334 ENSMUSG00000024844 UniProt O75531 O54962 RefSeq (mRNA) NM_003860 NM_001143985 NM_001038231 NM_001286608 NM_011793 RefSeq (protein) NP_001137457 NP_003851 NP_001033320 NP_001273537 NP_035923 Location (UCSC) Chr 11: 66 – 66 Mb Chr 19: 5.41 – 5.42 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the nuclear lamina.^[6] It also associates with the LEM Domain containing proteins LAP2, Emerin, and MAN1. The protein's DNA binding ability is modulated by ATP concentration.^[7]

Interactions

Barrier to autointegration factor 1 has been shown to interact with Thymopoietin.^[8]

Clinical relevance

Mutations in this gene have been shown to cause hereditary progeroid syndrome.^[9]

See also

• Retroviral integration