Basal cell adhesion molecule

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene.^[5] BCAM has also recently been designated CD239 (cluster of differentiation 239).

BCAM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PET, 2PF6
Identifiers
Aliases	BCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group)
External IDs	OMIM: 612773; MGI: 1929940; HomoloGene: 21149; GeneCards: BCAM; OMA:BCAM - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 44,809,071 bp[1] End 44,821,421 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 19,490,056 bp[2] End 19,504,941 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left lobe of thyroid gland popliteal artery tibial arteries right lobe of thyroid gland right coronary artery renal medulla left coronary artery apex of heart canal of the cervix Top expressed in interventricular septum lip molar right lung lumbar spinal ganglion left lung right lung lobe left lung lobe genital tubercle tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function laminin receptor activity protein C-terminus binding protein binding laminin binding transmembrane signaling receptor activity Cellular component integral component of membrane cell surface plasma membrane integral component of plasma membrane extracellular exosome membrane external side of plasma membrane extracellular matrix extracellular region collagen-containing extracellular matrix Biological process cell adhesion cell-matrix adhesion signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4059 57278 Ensembl ENSG00000187244 ENSMUSG00000002980 UniProt P50895 Q9R069 RefSeq (mRNA) NM_005581 NM_001013257 NM_020486 RefSeq (protein) NP_001013275 NP_005572 NP_065232 Location (UCSC) Chr 19: 44.81 – 44.82 Mb Chr 7: 19.49 – 19.5 Mb PubMed search [3] [4]
Wikidata
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Function

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.^[6][7][8]