Bcl-2-interacting killer

Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene.^[5][6][7]

BIK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IPE
Identifiers
Aliases	BIK, BIP1, BP4, NBK, BCL2 interacting killer
External IDs	OMIM: 603392; MGI: 1206591; HomoloGene: 924; GeneCards: BIK; OMA:BIK - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 43,110,750 bp[1] End 43,129,712 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,411,063 bp[2] End 83,428,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium olfactory zone of nasal mucosa palpebral conjunctiva mucosa of transverse colon gonad epithelium of bronchus bronchial epithelial cell mucosa of sigmoid colon minor salivary glands mucosa of paranasal sinus Top expressed in right kidney lumbar spinal ganglion proximal tubule embryo conjunctival fornix primary oocyte zygote transitional epithelium of urinary bladder right lung lobe lumbar subsegment of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding BH domain binding protein heterodimerization activity Cellular component integral component of membrane endomembrane system mitochondrial membranes mitochondrion membrane Biological process regulation of apoptotic process positive regulation of protein homooligomerization positive regulation of release of cytochrome c from mitochondria apoptotic process male gonad development apoptotic mitochondrial changes Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 638 12124 Ensembl ENSG00000100290 ENSMUSG00000016758 UniProt Q13323 O70337 RefSeq (mRNA) NM_001197 NM_007546 RefSeq (protein) NP_001188 NP_001188.1 NP_031572 Location (UCSC) Chr 22: 43.11 – 43.13 Mb Chr 15: 83.41 – 83.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein–Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.^[7]

Interactions

Bcl-2-interacting killer has been shown to interact with BCL2-like 1^{[8][9][10][11]} and Bcl-2.^[9][10]