Bone morphogenetic protein 3

Not to be confused with BMP-3.

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.^[5]

BMP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QCQ
Identifiers
Aliases	BMP3, BMP-3A, bone morphogenetic protein 3
External IDs	OMIM: 112263; MGI: 88179; HomoloGene: 927; GeneCards: BMP3; OMA:BMP3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.21 Start 81,030,708 bp[1] End 81,057,627 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E3|5 48.24 cM Start 99,002,274 bp[2] End 99,032,255 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon testicle rectum transverse colon mucosa of transverse colon tibial nerve olfactory zone of nasal mucosa palpebral conjunctiva gallbladder epithelium of colon Top expressed in perichondrium lower lip upper lip urinary bladder nucleus pulposus cervical ganglion urethra skeleton facial skeleton ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity BMP receptor binding transforming growth factor beta receptor binding growth factor activity signaling receptor binding Cellular component extracellular region extracellular exosome extracellular space Biological process regulation of apoptotic process skeletal system development cell differentiation regulation of MAPK cascade SMAD protein signal transduction cell development ossification cell-cell signaling positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway multicellular organism development cartilage development osteoblast differentiation regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 651 110075 Ensembl ENSG00000152785 ENSMUSG00000029335 UniProt P12645 Q8BHE5 RefSeq (mRNA) NM_001201 NM_173404 NM_001310677 RefSeq (protein) NP_001192 NP_001297606 NP_775580 Location (UCSC) Chr 4: 81.03 – 81.06 Mb Chr 5: 99 – 99.03 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other bone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Cancer

BMP3 is hypermethylated in many cases of colorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as a biomarker to detect early stage CRC.^[6][7]