Brevican

Brevican core protein is a protein that in humans is encoded by the BCAN gene.^[5][6][7] Brevican is a member of the lectican protein family.

BCAN
Identifiers
Aliases	BCAN, BEHAB, CSPG7, Brevican
External IDs	OMIM: 600347; MGI: 1096385; HomoloGene: 7244; GeneCards: BCAN; OMA:BCAN - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 156,641,390 bp[1] End 156,659,532 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.78 cM Start 87,987,531 bp[2] End 88,000,230 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone amygdala anterior cingulate cortex right frontal lobe nucleus accumbens caudate nucleus putamen ganglionic eminence prefrontal cortex Brodmann area 9 Top expressed in superior frontal gyrus entorhinal cortex primary visual cortex perirhinal cortex CA3 field dentate gyrus of hippocampal formation granule cell cerebellar cortex central gray substance of midbrain nucleus of stria terminalis superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hyaluronic acid binding carbohydrate binding extracellular matrix structural constituent Cellular component membrane extracellular region lysosomal lumen Golgi lumen anchored component of membrane extracellular matrix glutamatergic synapse Biological process skeletal system development chondroitin sulfate biosynthetic process extracellular matrix organization central nervous system development chondroitin sulfate catabolic process dermatan sulfate biosynthetic process hippocampus development cell adhesion synapse maturation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63827 12032 Ensembl ENSG00000132692 ENSMUSG00000004892 UniProt Q96GW7 Q61361 RefSeq (mRNA) NM_021948 NM_198427 NM_001109758 NM_007529 RefSeq (protein) NP_068767 NP_940819 NP_001103228 NP_031555 Location (UCSC) Chr 1: 156.64 – 156.66 Mb Chr 3: 87.99 – 88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Brevican is localised to the surface of neurons in the brain.^[8] In melanocytic cells, BCAN gene expression may be regulated by MITF.^[9]

Brevican is involved in maintaining molecule networks around neurons and may possibly be associated with slower brain ageing and Alzheimer's prevention.^[10]