Bridging integrator 3

Bridging integrator 3 is a protein that in humans is encoded by the BIN3 gene.^[5][6]

BIN3
Identifiers
Aliases	BIN3, bridging integrator 3
External IDs	OMIM: 606396; MGI: 1929883; HomoloGene: 5472; GeneCards: BIN3; OMA:BIN3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,620,418 bp[1] End 22,669,148 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 70,337,554 bp[2] End 70,375,655 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right adrenal cortex left adrenal gland left adrenal cortex oocyte blood right uterine tube olfactory zone of nasal mucosa granulocyte stromal cell of endometrium Top expressed in granulocyte fetal liver hematopoietic progenitor cell spermatocyte tibiofemoral joint zygote secondary oocyte mesenteric lymph nodes blood stroma of bone marrow skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal anchor activity protein binding cytoskeletal protein binding lipid binding Cellular component cytoplasm cytoskeleton actin filament actin cortical patch Biological process regulation of lamellipodium assembly unidimensional cell growth protein localization division septum assembly cell cycle myoblast migration involved in skeletal muscle regeneration skeletal muscle fiber development skeletal muscle tissue regeneration actin filament organization cell division cytoskeleton-dependent cytokinesis endocytosis actin cortical patch localization plasma membrane tubulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55909 57784 Ensembl ENSG00000147439 ENSMUSG00000022089 UniProt Q9NQY0 Q9JI08 RefSeq (mRNA) NM_018688 NM_001363046 NM_021328 NM_001360404 RefSeq (protein) NP_061158 NP_001349975 NP_067303 NP_001347333 Location (UCSC) Chr 8: 22.62 – 22.67 Mb Chr 14: 70.34 – 70.38 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene is a member of the BAR domain protein family. The encoded protein is composed solely of a BAR domain which is predicted to form coiled coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.^[6]