C-C motif chemokine ligand 3 like 3

C-C motif chemokine ligand 3 like 3 is a protein that in humans is encoded by the CCL3L3 gene. ^[5]

CCL3L3
Identifiers
Aliases	CCL3L3, 464.2, D17S1718, G0S19-2, LD78, LD78BETA, SCYA3L, SCYA3L1, C-C motif chemokine ligand 3 like 3
External IDs	OMIM: 609468; MGI: 98260; HomoloGene: 2242; GeneCards: CCL3L3; OMA:CCL3L3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 36,194,869 bp[1] End 36,196,758 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 51.04 cM Start 83,538,670 bp[2] End 83,540,181 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow monocyte bone marrow cell testicle gonad lymph node appendix blood granulocyte spleen Top expressed in granulocyte stroma of bone marrow calvaria spermatid blood dermis secondary oocyte thymus islet of Langerhans right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function chemokine activity cytokine activity CCR chemokine receptor binding Cellular component extracellular region extracellular space Biological process lymphocyte chemotaxis chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway positive regulation of GTPase activity cellular response to tumor necrosis factor chemotaxis inflammatory response cellular response to interleukin-1 monocyte chemotaxis neutrophil chemotaxis negative regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade immune response cellular response to interferon-gamma regulation of signaling receptor activity cytokine-mediated signaling pathway positive regulation of inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 414062 20302 Ensembl ENSG00000276085 ENSMUSG00000000982 UniProt P16619 P10855 RefSeq (mRNA) NM_001001437 NM_011337 RefSeq (protein) NP_001001437 NP_066286 NP_035467 Location (UCSC) Chr 17: 36.19 – 36.2 Mb Chr 11: 83.54 – 83.54 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.