Baculoviral IAP repeat-containing protein 2

Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene.^[5][6]

BIRC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4, 4EB9, 4HY4, 4HY5, 4KMN, 4LGE, 4LGU, 4MTI, 4MU7
Identifiers
Aliases	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, baculoviral IAP repeat containing 2
External IDs	OMIM: 601712; MGI: 1197009; HomoloGene: 900; GeneCards: BIRC2; OMA:BIRC2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.2 Start 102,347,211 bp[1] End 102,378,670 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 7,818,228 bp[2] End 7,837,065 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue secondary oocyte endothelial cell epithelium of nasopharynx germinal epithelium tibia visceral pleura parietal pleura pancreatic ductal cell ventricular zone Top expressed in spermatocyte blood spermatid mesenteric lymph nodes spleen seminiferous tubule conjunctival fornix pituitary gland Gonadal ridge thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding metal ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding transferase activity ubiquitin binding chaperone binding FBXO family protein binding zinc ion binding transcription coactivator activity ubiquitin-protein transferase activity identical protein binding ubiquitin protein ligase activity Cellular component cytosol XY body membrane raft CD40 receptor complex cytoplasmic side of plasma membrane nucleus cytoplasm protein-containing complex Biological process regulation of apoptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway positive regulation of protein K63-linked ubiquitination response to hypoxia regulation of transcription, DNA-templated regulation of innate immune response response to organic cyclic compound negative regulation of ripoptosome assembly involved in necroptotic process inhibition of cysteine-type endopeptidase activity involved in apoptotic process placenta development regulation of cysteine-type endopeptidase activity regulation of RIG-I signaling pathway regulation of tumor necrosis factor-mediated signaling pathway tumor necrosis factor-mediated signaling pathway regulation of reactive oxygen species metabolic process transcription, DNA-templated positive regulation of protein monoubiquitination mitotic spindle assembly cell surface receptor signaling pathway NIK/NF-kappaB signaling regulation of cell population proliferation response to organonitrogen compound positive regulation of protein K48-linked ubiquitination response to cAMP response to ethanol I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process necroptosis apoptotic process protein deubiquitination cellular response to tumor necrosis factor regulation of NIK/NF-kappaB signaling positive regulation of protein polyubiquitination negative regulation of necroptotic process protein polyubiquitination regulation of toll-like receptor signaling pathway negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of cell differentiation regulation of inflammatory response regulation of cell cycle regulation of necroptotic process protein heterooligomerization positive regulation of nucleic acid-templated transcription MyD88-independent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway positive regulation of protein ubiquitination negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 329 11797 Ensembl ENSG00000110330 ENSMUSG00000057367 UniProt Q13490 Q62210 RefSeq (mRNA) NM_001256166 NM_001166 NM_001256163 NM_007465 NM_001291503 RefSeq (protein) NP_001157 NP_001243092 NP_001243095 NP_001278432 NP_031491 Location (UCSC) Chr 11: 102.35 – 102.38 Mb Chr 9: 7.82 – 7.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

cIAP1 is a member of the Inhibitor of Apoptosis family that inhibit apoptosis by interfering with the activation of caspases.

Interactions

BIRC2 has been shown to interact with:

• CASP9,^[7]
• DIABLO,^[8][9]
• GSPT1,^[8]
• HSP90B1,^[10]
• HTRA2,^[8][11]
• RIPK1,^[12]
• RIPK2^[13][14]
• TNFSF14,^[15]
• TRAF1,^[16][17][18]
• TRAF2,^{[16][17][18][19][20][21]} and
• UBC.^[10][12][22]