GSPT1

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene.^[5][6][7]

GSPT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E1Y, 3J5Y, 4D61, 5HXB
Identifiers
Aliases	GSPT1, 551G9.2, ETF3A, GST1, eRF3a, G1 to S phase transition 1
External IDs	OMIM: 139259; MGI: 1316728; HomoloGene: 68226; GeneCards: GSPT1; OMA:GSPT1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.13 Start 11,868,128 bp[1] End 11,916,082 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 6.38 cM Start 11,037,156 bp[2] End 11,072,189 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium epithelium of colon trabecular bone islet of Langerhans gastrocnemius muscle ventricular zone mucosa of sigmoid colon blood ganglionic eminence parotid gland Top expressed in tail of embryo epiblast ventricular zone abdominal wall somite primitive streak dermis endothelial cell of lymphatic vessel morula seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding translation release factor activity protein binding GTPase activity RNA binding Cellular component translation release factor complex intracellular anatomical structure cytosol Biological process G1 phase nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis cytoplasmic translational termination protein methylation translational termination G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2935 14852 Ensembl ENSG00000103342 ENSMUSG00000062203 UniProt P15170 Q8R050 RefSeq (mRNA) NM_002094 NM_001130006 NM_001130007 NM_001130008 NM_146066 RefSeq (protein) NP_001123478 NP_001123479 NP_002085 NP_001123480 NP_666178 Location (UCSC) Chr 16: 11.87 – 11.92 Mb Chr 16: 11.04 – 11.07 Mb PubMed search [3] [4]
Wikidata
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Interactions

GSPT1 has been shown to interact with BIRC2.^[8]