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C1D

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

C1D
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Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene.[5][6][7][8][9][10] The C1D protein is encoded by a DNA binding gene traced in the nucleus.[11] Protein C1D has a chromosomal location of 2p14.[12] C1D has a family of proteins consisting of C1D homologues which may include Sas10 domains.[13] C1D is thought to bind to RNA and DNA where it may be involved in mechanisms of DNA repair.[13] Protein C1D is ubiquitously expressed in different human tissues.[14]

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Function

Despite inducing denaturing conditions, C1D shows high-affinity binding to DNA.[13] C1D has demonstrated capability to bind to DNA in DNA repair pathways.[13]

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Protein C1D may have a protective effect against relation to the TRAX/Translin complex formation of DNA.[13] Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.[10]

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Interactions

C1D has been shown to interact with TSNAX[8] and DNA-PKcs.[15] C1D has also shown to interact notably in mammalian cells and yeast.[16] Interaction in mammalian cells only occur ensuing gamma-irradiation.[16]

Protein expression

The protein C1D is thought to be expressed ubiquitously.[14] It may be expressed in high levels in the mammary gland, thyroid gland, salivary gland, medulla oblongata, and hippocampus.[14] It may be expressed at lower levels in the appendix, heart, lungs, skeletal muscles, and colon.[14]

References

Further reading

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