C1orf38

Chromosome 1 open reading frame 38 is a protein that in humans is encoded by the C1orf38 gene.^[5] The gene is also known as ICB-1 and THEMIS2 in humans, and the orthologue in mice is BC013712.^[5] C1orf38 has been associated with cancer susceptibility.^[6]

THEMIS2
Identifiers
Aliases	THEMIS2, C1orf38, ICB-1, thymocyte selection associated family member 2, ICB1, Chromosome 1 open reading frame 38
External IDs	OMIM: 617856; MGI: 2446213; HomoloGene: 21009; GeneCards: THEMIS2; OMA:THEMIS2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 27,872,543 bp[1] End 27,886,685 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,509,154 bp[2] End 132,523,698 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood spleen bone marrow cell right lung upper lobe of left lung appendix C1 segment gallbladder Top expressed in granulocyte lymph node spleen mesenteric lymph nodes blood stroma of bone marrow gastrula subcutaneous adipose tissue submandibular gland tibiofemoral joint More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus cytoplasm Biological process inflammatory response immune system process cell adhesion T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9473 230787 Ensembl ENSG00000130775 ENSMUSG00000037731 UniProt Q5TEJ8 Q91YX0 RefSeq (mRNA) NM_001039477 NM_001105556 NM_001286113 NM_001286115 NM_004848 NM_001033308 RefSeq (protein) NP_001034566 NP_001099026 NP_001273042 NP_001273044 NP_004839 NP_001028480 Location (UCSC) Chr 1: 27.87 – 27.89 Mb Chr 4: 132.51 – 132.52 Mb PubMed search [3] [4]
Wikidata
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