C3a receptor

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.^[5][6]

C3AR1
Identifiers
Aliases	C3AR1, AZ3B, C3AR, HNFAG09, complement component 3a receptor 1, complement C3a receptor 1
External IDs	OMIM: 605246; MGI: 1097680; HomoloGene: 2992; GeneCards: C3AR1; OMA:C3AR1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 8,056,844 bp[1] End 8,066,359 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F2 Start 122,824,097 bp[2] End 122,833,120 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone decidua amniotic fluid bone marrow blood appendix lower lobe of lung bone marrow cells superficial temporal artery Top expressed in stroma of bone marrow calvaria ankle joint ankle lumbar subsegment of spinal cord internal carotid artery external carotid artery sciatic nerve white adipose tissue carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity complement receptor activity complement component C3a receptor activity G protein-coupled receptor activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane azurophil granule membrane specific granule membrane Biological process blood circulation signal transduction chemotaxis positive regulation of neutrophil chemotaxis positive regulation of angiogenesis positive regulation of macrophage chemotaxis inflammatory response positive regulation of vascular endothelial growth factor production G protein-coupled receptor signaling pathway regulation of complement activation phospholipase C-activating G protein-coupled receptor signaling pathway neutrophil degranulation leukocyte migration cell chemotaxis complement receptor mediated signaling pathway positive regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 719 12267 Ensembl ENSG00000171860 ENSMUSG00000040552 UniProt Q16581 O09047 RefSeq (mRNA) NM_004054 NM_001326475 NM_001326477 NM_009779 RefSeq (protein) NP_001313404 NP_001313406 NP_004045 NP_033909 Location (UCSC) Chr 12: 8.06 – 8.07 Mb Chr 6: 122.82 – 122.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans.^[7] C3a receptor modulates immunity,^[8] arthritis, diet-induced obesity^[9] and cancers.^[10]

Agonists and antagonists

Potent and selective agonists^[11] and antagonists^[12] for C3aR have been discovered.