Carbonic anhydrase 5B, mitochondrial

Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene.^[5][6]

CA5B
Identifiers
Aliases	CA5B, CA-VB, carbonic anhydrase 5B, CAVB
External IDs	OMIM: 300230; MGI: 1926249; HomoloGene: 21413; GeneCards: CA5B; OMA:CA5B - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 15,688,830 bp[1] End 15,788,411 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 162,759,818 bp[2] End 162,810,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon monocyte granulocyte ascending aorta right coronary artery tibial arteries canal of the cervix Descending thoracic aorta left ovary right ovary Top expressed in white adipose tissue right kidney mammary gland seminal vesicula subcutaneous adipose tissue brown adipose tissue proximal tubule human kidney intercostal muscle tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lyase activity metal ion binding zinc ion binding carbonate dehydratase activity carbonic anhydrase Cellular component mitochondrial matrix mitochondrion Biological process bicarbonate transport response to bacterium one-carbon metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11238 56078 Ensembl ENSG00000169239 ENSMUSG00000031373 UniProt Q9Y2D0 Q9QZA0 RefSeq (mRNA) NM_007220 NM_181315 RefSeq (protein) NP_009151 NP_009151.1 NP_851832 Location (UCSC) Chr X: 15.69 – 15.79 Mb Chr X: 162.76 – 162.81 Mb PubMed search [3] [4]
Wikidata
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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.^[6]