CAB39

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.^[5]

CAB39
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UPK, 1UPL, 2WTK, 3GNI, 4FZA, 4FZD, 4FZF, 4NZW, 4O27
Identifiers
Aliases	CAB39, MO25, CGI-66, calcium binding protein 39
External IDs	OMIM: 612174; MGI: 107438; HomoloGene: 69212; GeneCards: CAB39; OMA:CAB39 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 230,712,842 bp[1] End 230,821,075 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 85,721,162 bp[2] End 85,779,297 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid tibia middle temporal gyrus Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii mucosa of sigmoid colon palpebral conjunctiva glutes cartilage tissue triceps brachii muscle Top expressed in facial motor nucleus muscle of thigh anterior horn of spinal cord plantaris muscle transitional epithelium of urinary bladder soleus muscle extensor digitorum longus muscle gastrocnemius muscle parotid gland tibialis anterior muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activator activity protein kinase activator activity protein serine/threonine kinase activity kinase binding protein binding Cellular component cytoplasm cytosol serine/threonine protein kinase complex extracellular exosome extracellular region secretory granule lumen ficolin-1-rich granule lumen protein-containing complex Biological process intracellular signal transduction protein heterooligomerization signal transduction cellular hypotonic response positive regulation of protein serine/threonine kinase activity negative regulation of potassium ion transmembrane transporter activity positive regulation of peptidyl-threonine phosphorylation peptidyl-serine phosphorylation negative regulation of potassium ion transmembrane transport activation of protein kinase activity neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51719 12283 Ensembl ENSG00000135932 ENSMUSG00000036707 UniProt Q9Y376 Q06138 RefSeq (mRNA) NM_001130849 NM_001130850 NM_016289 NM_133781 NM_001355046 NM_001355047 RefSeq (protein) NP_001124321 NP_001124322 NP_057373 NP_598542 NP_001341975 NP_001341976 Location (UCSC) Chr 2: 230.71 – 230.82 Mb Chr 1: 85.72 – 85.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).^[6] CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.^[6]