CABYR

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.^[5][6][7][8]

CABYR
Identifiers
Aliases	CABYR, CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, calcium binding tyrosine phosphorylation regulated
External IDs	OMIM: 612135; MGI: 1918382; HomoloGene: 49299; GeneCards: CABYR; OMA:CABYR - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 24,138,987 bp[1] End 24,161,600 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 12,873,379 bp[2] End 12,888,317 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis gonad oocyte right uterine tube secondary oocyte anterior pituitary anterior cingulate cortex testicle Top expressed in seminiferous tubule spermatid spermatocyte primary visual cortex ascending aorta superior frontal gyrus aortic valve dentate gyrus of hippocampal formation granule cell embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding enzyme binding calcium ion binding protein binding protein domain specific binding metal ion binding protein heterodimerization activity Cellular component cytoplasm sperm principal piece cell projection motile cilium cilium sperm fibrous sheath cytoskeleton nucleus sperm end piece cytosol extracellular region Biological process sperm capacitation epithelial cilium movement involved in extracellular fluid movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26256 71132 Ensembl ENSG00000154040 ENSMUSG00000024430 UniProt O75952 Q9D424 RefSeq (mRNA) NM_001308231 NM_012189 NM_138643 NM_138644 NM_153768 NM_153769 NM_153770 NM_001042418 NM_001042419 NM_001042420 NM_027687 NM_181731 RefSeq (protein) NP_001295160 NP_036321 NP_619584 NP_619585 NP_722452 NP_722453 NP_722454 NP_001295160.1 NP_001035883 NP_001035884 NP_001035885 NP_081963 NP_859420 Location (UCSC) Chr 18: 24.14 – 24.16 Mb Chr 18: 12.87 – 12.89 Mb PubMed search [3] [4]
Wikidata
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To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.^[8]