CACNA1B

The voltage-dependent N-type calcium channel subunit alpha-1B is a protein that in humans is encoded by the CACNA1B gene.^[5][6][7] The α1B protein, together with β and α2δ subunits forms an N-type calcium channel (Ca_v2.2 channel).^[8]

CACNA1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LCM
Identifiers
Aliases	CACNA1B, BIII, CACNL1A5, CACNN, Cav2.2, DYT23, calcium voltage-gated channel subunit alpha1 B, NEDNEH
External IDs	OMIM: 601012; MGI: 88296; HomoloGene: 20184; GeneCards: CACNA1B; OMA:CACNA1B - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,877,782 bp[1] End 138,124,624 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 16.58 cM Start 24,493,899 bp[2] End 24,653,164 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 postcentral gyrus endothelial cell superior frontal gyrus entorhinal cortex right hemisphere of cerebellum primary visual cortex Brodmann area 46 cerebellar vermis Top expressed in supraoptic nucleus ventromedial nucleus dorsomedial hypothalamic nucleus anterior amygdaloid area trigeminal ganglion gastrula subiculum arcuate nucleus lumbar spinal ganglion mammillary body More reference expression data BioGPS n/a
Gene ontology Molecular function protein C-terminus binding metal ion binding nucleotide binding calcium ion binding voltage-gated calcium channel activity high voltage-gated calcium channel activity ion channel activity ATP binding voltage-gated ion channel activity protein binding calcium channel activity amyloid-beta binding Cellular component integral component of membrane presynapse membrane soma dendrite voltage-gated calcium channel complex plasma membrane Biological process calcium ion transport chemical synaptic transmission transmembrane transport membrane depolarization during action potential locomotory behavior regulation of ion transmembrane transport regulation of blood pressure regulation of calcium ion transport ion transport regulation of heart contraction calcium ion transmembrane transport response to pain membrane depolarization neurotransmitter secretion calcium ion import modulation of chemical synaptic transmission response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 774 12287 Ensembl ENSG00000148408 ENSMUSG00000004113 UniProt Q00975 O55017 RefSeq (mRNA) NM_000718 NM_001243812 NM_001042528 NM_007579 RefSeq (protein) NP_000709 NP_001230741 NP_001035993 NP_031605 Location (UCSC) Chr 9: 137.88 – 138.12 Mb Chr 2: 24.49 – 24.65 Mb PubMed search [3] [4]
Wikidata
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