CACNG3

Voltage-dependent calcium channel gamma-3 subunit is a protein that in humans is encoded by the CACNG3 gene.^[5][6][7]

CACNG3
Identifiers
Aliases	CACNG3, calcium voltage-gated channel auxiliary subunit gamma 3
External IDs	OMIM: 606403; MGI: 1859165; HomoloGene: 4767; GeneCards: CACNG3; OMA:CACNG3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.1 Start 24,256,335 bp[1] End 24,362,412 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 122,269,715 bp[2] End 122,368,616 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 Brodmann area 46 orbitofrontal cortex Region I of hippocampus proper dorsolateral prefrontal cortex superior frontal gyrus gonad right frontal lobe postcentral gyrus cingulate gyrus Top expressed in superior frontal gyrus primary visual cortex prefrontal cortex dentate gyrus of hippocampal formation granule cell piriform cortex primary motor cortex olfactory tubercle cingulate gyrus neural layer of retina lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated calcium channel activity voltage-gated ion channel activity channel regulator activity calcium channel activity PDZ domain binding ionotropic glutamate receptor binding Cellular component voltage-gated calcium channel complex integral component of membrane endocytic vesicle membrane plasma membrane AMPA glutamate receptor complex membrane somatodendritic compartment dendrite excitatory synapse postsynaptic density membrane Schaffer collateral - CA1 synapse glutamatergic synapse integral component of postsynaptic density membrane Biological process transmission of nerve impulse regulation of ion transmembrane transport ion transport calcium ion transmembrane transport calcium ion transport regulation of AMPA receptor activity protein targeting protein localization positive regulation of AMPA receptor activity neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of synaptic transmission, glutamatergic neurotransmitter receptor transport, postsynaptic endosome to lysosome postsynaptic neurotransmitter receptor diffusion trapping neurotransmitter receptor internalization cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10368 54376 Ensembl ENSG00000006116 ENSMUSG00000066189 UniProt O60359 Q9JJV5 RefSeq (mRNA) NM_006539 NM_019430 RefSeq (protein) NP_006530 NP_062303 Location (UCSC) Chr 16: 24.26 – 24.36 Mb Chr 7: 122.27 – 122.37 Mb PubMed search [3] [4]
Wikidata
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L-type calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This protein is similar to the mouse stargazin protein, mutations in which have been associated with absence seizures, also known as petit-mal or spike-wave seizures. This gene is a member of the neuronal calcium channel gamma subunit gene subfamily of the PMP-22/EMP/MP20 family. This gene is a candidate gene for a familial infantile convulsive disorder with paroxysmal choreoathetosis.^[7]

See also

• Voltage-dependent calcium channel