CACYBP

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.^[5][6][7]

CACYBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X5M, 2A25, 2A26
Identifiers
Aliases	CACYBP, GIG5, S100A6BP, SIP, PNAS-107, calcyclin binding protein
External IDs	OMIM: 606186; MGI: 1270839; HomoloGene: 7649; GeneCards: CACYBP; OMA:CACYBP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1 Start 174,999,163 bp[1] End 175,012,027 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.1 Start 160,029,937 bp[2] End 160,040,445 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pons postcentral gyrus entorhinal cortex superior frontal gyrus middle temporal gyrus Brodmann area 46 Brodmann area 23 orbitofrontal cortex ventricular zone Top expressed in primitive streak abdominal wall tail of embryo mandibular prominence genital tubercle maxillary prominence somite yolk sac arcuate nucleus dorsomedial hypothalamic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity protein domain specific binding ubiquitin protein ligase binding tubulin binding S100 protein binding Cellular component nuclear envelope lumen extracellular exosome beta-catenin destruction complex nucleus nucleoplasm neuron projection cell body cytoplasm cytosol SCF ubiquitin ligase complex Biological process cardiac muscle cell differentiation positive regulation of DNA replication ageing negative regulation of cell death cellular response to calcium ion heart development response to growth hormone cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27101 12301 Ensembl ENSG00000116161 ENSMUSG00000014226 UniProt Q9HB71 Q9CXW3 RefSeq (mRNA) NM_014412 NM_001007214 NM_009786 RefSeq (protein) NP_001007215 NP_055227 NP_033916 Location (UCSC) Chr 1: 175 – 175.01 Mb Chr 1: 160.03 – 160.04 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[7]

Protein Interactions

CACYBP has been shown to interact with SKP1A^[8] and SIAH1.^[5]

The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90.^[9]