Cell adhesion molecule 1

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.^[5][6]

CADM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BIN, 4H5S
Identifiers
Aliases	CADM1, BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1, cell adhesion molecule 1
External IDs	OMIM: 605686; MGI: 1889272; HomoloGene: 8641; GeneCards: CADM1; OMA:CADM1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 115,169,218 bp[1] End 115,504,957 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 47,530,173 bp[2] End 47,858,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in paraflocculus of cerebellum Pons periodontal fiber Achilles tendon caput epididymis corpus callosum visceral pleura islet of Langerhans spinal ganglia beta cell Top expressed in epithelium of lens otic placode ciliary body subiculum otic vesicle iris CA3 field saccule neural layer of retina Amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding protein homodimerization activity protein binding signaling receptor binding cell adhesion molecule binding Cellular component integral component of membrane membrane cell-cell junction synapse integral component of plasma membrane cell junction basolateral plasma membrane plasma membrane Biological process cell differentiation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules activated T cell proliferation immune system process multicellular organism development cell adhesion spermatogenesis adherens junction organization T cell mediated cytotoxicity homophilic cell adhesion via plasma membrane adhesion molecules apoptotic process susceptibility to natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity detection of stimulus cell recognition viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23705 54725 Ensembl ENSG00000182985 ENSMUSG00000032076 UniProt Q9BY67 Q8R5M8 RefSeq (mRNA) NM_001098517 NM_001301043 NM_001301044 NM_001301045 NM_014333 NM_001025600 NM_018770 NM_207675 NM_207676 NM_001310841 RefSeq (protein) NP_001091987 NP_001287972 NP_001287973 NP_001287974 NP_055148 NP_001020771 NP_001297770 NP_061240 NP_997558 NP_997559 Location (UCSC) Chr 11: 115.17 – 115.5 Mb Chr 9: 47.53 – 47.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Cell adhesion molecule 1 has been shown to interact with EPB41L3.^[7]

Association studies

Genome-wide association studies identified an association between body mass index and two loci near the CADM1 and CADM2 gene.^[8] Experimental results of another study showed that obese mice had an over expression of both CADM1 and CADM2 genes, and that loss of CADM1 protected mice from obesity, promoting a negative energy balance and weight loss.^[9] Furthermore, a 2019 GWAS study revealed an association between Anorexia nervosa and CADM1.^[10] In the brain, this genes mediate synaptic assembly, and mutations in CADM1 are also associated with Autistic spectrum disorder. ^[11]

See also

• Cell adhesion molecule
• Nectin