CAMK1D

Calcium/calmodulin-dependent protein kinase ID is a protein in humans that is encoded by the CAMK1D gene on chromosome 10 (locus 10p13).^[5]

CAMK1D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JC6
Identifiers
Aliases	CAMK1D, CKLiK, CaM-K1, CaMKID, calcium/calmodulin dependent protein kinase ID
External IDs	OMIM: 607957; MGI: 2442190; HomoloGene: 121858; GeneCards: CAMK1D; OMA:CAMK1D - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 12,349,547 bp[1] End 12,835,545 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 5,298,268 bp[2] End 5,719,326 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus parietal lobe postcentral gyrus Brodmann area 23 cerebellar vermis superior frontal gyrus entorhinal cortex nipple primary visual cortex trigeminal ganglion Top expressed in olfactory tubercle piriform cortex primary motor cortex medial geniculate nucleus retinal pigment epithelium dentate gyrus subdivision of hippocampus Region I of hippocampus proper amygdala anterior amygdaloid area More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity catalytic activity ATP binding calmodulin-dependent protein kinase activity calmodulin binding Cellular component nucleus cytoplasm Biological process regulation of granulocyte chemotaxis positive regulation of phagocytosis phosphorylation negative regulation of apoptotic process regulation of dendrite development nervous system development protein phosphorylation positive regulation of CREB transcription factor activity positive regulation of apoptotic process metabolism inflammatory response positive regulation of respiratory burst positive regulation of neutrophil chemotaxis positive regulation of neuron projection development peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57118 227541 Ensembl ENSG00000183049 ENSMUSG00000039145 UniProt Q8IU85 Q8BW96 RefSeq (mRNA) NM_020397 NM_153498 NM_001351032 NM_001290374 NM_001290375 NM_001290376 NM_177343 RefSeq (protein) NP_065130 NP_705718 NP_001337961 NP_001277303 NP_001277304 NP_001277305 NP_796317 Location (UCSC) Chr 10: 12.35 – 12.84 Mb Chr 2: 5.3 – 5.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Ca2+/calmodulin-dependent protein kinase 1 subfamily of serine/threonine kinases. The encoded protein may be involved in the regulation of granulocyte function through the chemokine signal transduction pathway. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

External links

• Human CAMK1D genome location and CAMK1D gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q8IU85 (Human Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)) at the PDBe-KB.