CAMK2B

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.

CAMK2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BHH
Identifiers
Aliases	CAMK2B, CAM2, CAMK2, CAMKB, calcium/calmodulin dependent protein kinase II beta, MRD54, CaMKIIbeta
External IDs	OMIM: 607707; MGI: 88257; HomoloGene: 111050; GeneCards: CAMK2B; OMA:CAMK2B - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,217,150 bp[1] End 44,334,577 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 3.89 cM Start 5,919,644 bp[2] End 6,016,362 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis lateral nuclear group of thalamus paraflocculus of cerebellum nucleus accumbens Parietal Lobe Brodmann area 9 right frontal lobe Top expressed in dentate gyrus of hippocampal formation granule cell CA3 field superior frontal gyrus primary visual cortex entorhinal cortex olfactory tubercle perirhinal cortex cerebellar cortex hippocampus proper nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity kinase activity protein binding actin binding ATP binding protein serine/threonine kinase activity calmodulin-dependent protein kinase activity calmodulin binding identical protein binding Cellular component endocytic vesicle membrane cytosol membrane plasma membrane nucleoplasm microtubule organizing center sarcoplasmic reticulum membrane sarcoplasmic reticulum cytoskeleton cytoplasm neuron projection cell junction synapse Biological process cell differentiation regulation of synapse structural plasticity regulation of calcium ion transport regulation of long-term neuronal synaptic plasticity interferon-gamma-mediated signaling pathway phosphorylation nervous system development MAPK cascade multicellular organism development positive regulation of synapse maturation protein phosphorylation positive regulation of neuron projection development protein autophosphorylation regulation of skeletal muscle adaptation positive regulation of dendritic spine morphogenesis regulation of dendritic spine development signal transduction peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction regulation of neuron migration regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 816 12323 Ensembl ENSG00000058404 ENSMUSG00000057897 UniProt Q13554 P28652 RefSeq (mRNA) NM_001220 NM_001293170 NM_172078 NM_172079 NM_172080 NM_172081 NM_172082 NM_172083 NM_172084 NM_001174053 NM_001174054 NM_007595 RefSeq (protein) NP_001211 NP_001280099 NP_742075 NP_742076 NP_742077 NP_742078 NP_742079 NP_742080 NP_742081 NP_001167524 NP_001167525 NP_031621 Location (UCSC) Chr 7: 44.22 – 44.33 Mb Chr 11: 5.92 – 6.02 Mb PubMed search [3] [4]
Wikidata
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Function

The enzyme belongs to the serine/threonine protein kinase family and to the Ca²⁺/calmodulin-dependent protein kinase subfamily. Calcium signalling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.^[5]

Interactions

CAMK2B has been shown to interact with Actinin alpha 4.^[6]