CAP1

Adenylyl cyclase-associated protein 1 is an enzyme that in humans is encoded by the CAP1 gene.^[4][5][6]

CAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K8F
Identifiers
Aliases	CAP1, CAP, CAP1-PEN, CAP, adenylate cyclase-associated protein 1 (yeast), adenylate cyclase associated protein 1
External IDs	OMIM: 617801; MGI: 88262; HomoloGene: 74572; GeneCards: CAP1; OMA:CAP1 - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse)[1] Band 4|4 D2.2 Start 122,752,840 bp[1] End 122,779,849 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in granulocyte lateral septal nucleus dentate gyrus of hippocampal formation granule cell superior frontal gyrus transitional epithelium of urinary bladder tibiofemoral joint cervix yolk sac decidua lip BioGPS More reference expression data
Gene ontology Molecular function adenylate cyclase binding actin binding Cellular component cytoplasm plasma membrane extracellular exosome membrane focal adhesion cortical actin cytoskeleton extracellular region extracellular space azurophil granule lumen Biological process establishment or maintenance of cell polarity ameboidal-type cell migration receptor-mediated endocytosis actin cytoskeleton organization cytoskeleton organization signal transduction activation of adenylate cyclase activity cell morphogenesis actin polymerization or depolymerization neutrophil degranulation regulation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10487 12331 Ensembl ENSG00000131236 ENSMUSG00000028656 UniProt Q01518 Q5T0R9 P40124 RefSeq (mRNA) NM_001105530 NM_006367 NM_001330502 NM_001301067 NM_007598 NM_001358035 NM_001358036 RefSeq (protein) NP_001099000 NP_001317431 NP_006358 NP_001337404 NP_001337405 NP_001337406 NP_001337407 NP_001337408 NP_001337409 NP_001337410 NP_001337411 NP_001337412 NP_001337413 NP_001337414 NP_001287996 NP_031624 NP_001344964 NP_001344965 Location (UCSC) n/a Chr 4: 122.75 – 122.78 Mb PubMed search [2] [3]
Wikidata
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The protein encoded by this gene is related to the Saccharomyces cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin.^[6]

Interactions

CAP1 has been shown to interact with ACTG1^[7] and CAP2.^[5]

See also

• Adenylyl cyclase