CAPN10

Calpain-10 is a protein that in humans is encoded by the CAPN10 gene.^[5][6]

CAPN10
Identifiers
Aliases	CAPN10, CANP10, NIDDM1, calpain 10
External IDs	OMIM: 605286; MGI: 1344392; HomoloGene: 36323; GeneCards: CAPN10; OMA:CAPN10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 240,586,734 bp[1] End 240,617,705 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 92,862,098 bp[2] End 92,875,663 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right hemisphere of cerebellum granulocyte spleen anterior pituitary right uterine tube right frontal lobe tibial nerve left testis right testis Top expressed in spermatocyte otic vesicle neural layer of retina yolk sac dentate gyrus of hippocampal formation granule cell lip saccule right kidney ventricular zone seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal protein binding peptidase activity cysteine-type peptidase activity hydrolase activity SNARE binding calcium-dependent cysteine-type endopeptidase activity Cellular component intracellular anatomical structure cytosol plasma membrane mitochondrion cytoplasm Biological process actin cytoskeleton reorganization positive regulation of glucose import cellular component disassembly involved in execution phase of apoptosis positive regulation of intracellular transport positive regulation of type B pancreatic cell apoptotic process proteolysis positive regulation of insulin secretion cellular response to insulin stimulus type B pancreatic cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11132 23830 Ensembl ENSG00000142330 ENSMUSG00000026270 UniProt Q9HC96 Q9ESK3 RefSeq (mRNA) NM_023089 NM_021251 NM_023083 NM_023084 NM_023085 NM_023086 NM_023087 NM_023088 NM_011796 RefSeq (protein) NP_075571 NP_075573 NP_035926 Location (UCSC) Chr 2: 240.59 – 240.62 Mb Chr 1: 92.86 – 92.88 Mb PubMed search [3] [4]
Wikidata
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Overview

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The typical calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. The heterodimer interface is predominantly found between domain IV and the small subunit, which is also a calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.^[7]