CASP8AP2

CASP8-associated protein 2 is a protein, that in humans is encoded by the CASP8AP2 gene.^[5][6][7][8]

CASP8AP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LR8
Identifiers
Aliases	CASP8AP2, CED-4, FLASH, RIP25, caspase 8 associated protein 2
External IDs	OMIM: 606880; MGI: 1349399; HomoloGene: 8066; GeneCards: CASP8AP2; OMA:CASP8AP2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,829,894 bp[1] End 89,874,436 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 14.27 cM Start 32,615,451 bp[2] End 32,653,265 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus callosum epithelium of colon testicle ventricular zone ganglionic eminence tonsil gonad endometrium lymph node Top expressed in zygote secondary oocyte primary oocyte genital tubercle tail of embryo cumulus cell primitive streak abdominal wall Gonadal ridge medial ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activator activity involved in apoptotic process DNA binding death receptor binding transcription corepressor activity SUMO polymer binding protein binding cysteine-type endopeptidase activator activity involved in apoptotic process Cellular component cytoplasm PML body mitochondrion nucleus nucleoplasm Biological process regulation of transcription, DNA-templated Fas signaling pathway transcription, DNA-templated cellular response to mechanical stimulus apoptotic signaling pathway cell cycle activation of cysteine-type endopeptidase activity involved in apoptotic process extrinsic apoptotic signaling pathway via death domain receptors signal transduction apoptotic process negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9994 26885 Ensembl ENSG00000118412 ENSG00000288475 ENSMUSG00000028282 UniProt Q9UKL3 Q9WUF3 RefSeq (mRNA) NM_012115 NM_001137667 NM_001137668 NM_001122978 NM_011997 RefSeq (protein) NP_001131139 NP_001131140 NP_036247 NP_001116450 NP_036127 Location (UCSC) Chr 6: 89.83 – 89.87 Mb Chr 4: 32.62 – 32.65 Mb PubMed search [3] [4]
Wikidata
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Function

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Researches of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex, that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis.^[8]

Interactions

CASP8AP2 has been shown to interact with TRAF2.^[9]