CBR3

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.^[5][6][7]

CBR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HRB
Identifiers
Aliases	CBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDs	OMIM: 603608; MGI: 1309992; HomoloGene: 20332; GeneCards: CBR3; OMA:CBR3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.12 Start 36,135,079 bp[1] End 36,146,562 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C4|16 54.58 cM Start 93,480,103 bp[2] End 93,487,878 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium tendon of biceps brachii olfactory zone of nasal mucosa parotid gland cartilage tissue minor salivary glands vulva oral cavity mucosa of pharynx Achilles tendon Top expressed in epithelium of stomach pyloric antrum mucous cell of stomach cervix esophagus stroma of bone marrow skin of external ear ankle joint lip dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity NADPH binding carbonyl reductase (NADPH) activity 3-keto sterol reductase activity protein binding Cellular component nucleoplasm extracellular space cytoplasm cytosol Biological process phylloquinone catabolic process cognition xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 874 109857 Ensembl ENSG00000159231 ENSMUSG00000022947 UniProt O75828 Q8K354 RefSeq (mRNA) NM_001236 NM_173047 RefSeq (protein) NP_001227 NP_766635 Location (UCSC) Chr 21: 36.14 – 36.15 Mb Chr 16: 93.48 – 93.49 Mb PubMed search [3] [4]
Wikidata
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Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.^[7]