CCBP2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

CCBP2

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[5][6][7]

Quick Facts ACKR2, Identifiers ...
ACKR2
Identifiers
AliasesACKR2, CCBP2, CCR10, CCR9, CMKBR9, D6, hD6, atypical chemokine receptor 2
External IDsOMIM: 602648; MGI: 1891697; HomoloGene: 992; GeneCards: ACKR2; OMA:ACKR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001296

NM_001276719
NM_021609

RefSeq (protein)

NP_001287

NP_001263648
NP_067622

Location (UCSC)Chr 3: 42.8 – 42.89 MbChr 9: 121.73 – 121.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[7]

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.