CCDC198

Coiled-Coil Domain Containing 198 (CCDC198) is a gene that encodes for a protein of the same name.^[5]

CCDC198
Identifiers
Aliases	CCDC198, C14orf105, chromosome 14 open reading frame 105, coiled-coil domain containing 198, FLJ10650
External IDs	MGI: 1914332; HomoloGene: 49528; GeneCards: CCDC198; OMA:CCDC198 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 57,469,300 bp[1] End 57,493,867 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 49,457,045 bp[2] End 49,482,931 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of pancreas right lobe of liver renal medulla gallbladder human kidney buccal mucosa cell kidney tubule caput epididymis testicle Top expressed in right kidney epithelium of small intestine renal pelvis human kidney spermatid migratory enteric neural crest cell proximal tubule seminiferous tubule efferent ductule renal calyx More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 55195 67082 Ensembl ENSG00000100557 ENSMUSG00000021850 UniProt Q9NVL8 Q9CPZ1 RefSeq (mRNA) NM_001283056 NM_001283057 NM_001283058 NM_001283059 NM_001283060 NM_018168 NM_025956 RefSeq (protein) NP_001269985 NP_001269986 NP_001269987 NP_001269988 NP_001269989 NP_060638 NP_001269985.1 NP_080232 Location (UCSC) Chr 14: 57.47 – 57.49 Mb Chr 14: 49.46 – 49.48 Mb PubMed search [3] [4]
Wikidata
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Bioinformation

Gene

The gene spans 24,570 bp on human chromosome 14.^[5]

Transcript

Isoform X2 of CCDC198 is 999 nucleotides long. CCDC198 is notably expressed in both the liver and the kidney.^[6]

Protein

CCDC198 has 296 amino acids and a molecular mass of 34.7 kilodaltons.^[6]

Phylogeny

The gene is confined within animals, as confident orthologs in fungi and choanoflagellates were not found. The human gene shares defined homology with placental mammals, marsupials, monotremes, reptiles, birds, amphibians, cartilaginous fish and some homology in insects, lobe finned fish, chelicerates and corals (Figure 22). The following significant taxonomic groups do not yield confident homology: nematodes, cnidaria, platyhelminths, porifera, annelids, ctenophora, mollusca, echinodermata, myriapoda, agnatha, tunicata. Crustacea is a borderline case that may yield homology. It is notable that there is a sharp cut off in sequence similarity outside of mammals, and a sharp drop in ortholog frequency outside of amniotes.^[7]

Expression

CCDC198 is primarily expressed in the kidneys, liver and pancreas, and also shows minor but significant expression in the fallopian tubes based on general NCBI profile data. Based on NCBI GEO microarray data on diverse cell tissue, it is expressed in the bladder, lung, midgut, gallbladder and fallopian tube as well, with minor expression in the testis and prostate.^[8][9][10]

Relation with ubiquitin-related modifier 1

An antibody has been developed to CCDC198 protein by Sigma-Aldrich.^[11] Known as Anti-C14orf105 or Anti-FLJ10650, it is synonymous with Anti-C9orf74, an antibody for the characterized Ubiquitin-related modifier 1 gene^[11]

Clinical significance

The X12 isoform of CCDC198 has proposed as a potential marker of infection by the liver fluke Opisthorchis viverrini^[12] Though normally expressed even in healthy individuals, CCDC198 has a threefold abundance in infected individuals.^[12] CCDC198 has more significant expression in those afflicted by alcoholic hepatitis.^[13]