CCDC85B

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.^[5][6][7]

CCDC85B
Identifiers
Aliases	CCDC85B, DIPA, coiled-coil domain containing 85B
External IDs	OMIM: 605360; MGI: 2147607; HomoloGene: 4989; GeneCards: CCDC85B; OMA:CCDC85B - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,890,673 bp[1] End 65,891,635 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,503,208 bp[2] End 5,507,922 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Amygdala Brodmann area 9 right frontal lobe nucleus accumbens putamen apex of heart caudate nucleus Region I of hippocampus proper cingulate gyrus anterior cingulate cortex Top expressed in anterior horn of spinal cord facial motor nucleus endothelial cell of lymphatic vessel epithelium of lens otolith organ utricle prefrontal cortex hippocampus proper primary motor cortex cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm centrosome cytoskeleton nucleus microtubule organizing center Biological process regulation of growth cell differentiation negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of cell growth transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11007 240514 Ensembl ENSG00000175602 ENSMUSG00000095098 UniProt Q15834 Q6PDY0 RefSeq (mRNA) NM_006848 NM_001243307 NM_198616 RefSeq (protein) NP_006839 NP_001230236 NP_941018 Location (UCSC) Chr 11: 65.89 – 65.89 Mb Chr 19: 5.5 – 5.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro.^[7]

Interactions

CCDC85B has been shown to interact with:

• C19orf25,^[8]
• KIAA1267,^[8]
• Keratin 17,^[8] and
• Protein kinase N1.^[8]