CCL19

Chemokine (C-C motif) ligand 19 (CCL19) is a protein that in humans is encoded by the CCL19 gene.^[5][6]

CCL19
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2MP1
Identifiers
Aliases	CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19, C-C motif chemokine ligand 19
External IDs	OMIM: 602227; MGI: 5434459; HomoloGene: 4569; GeneCards: CCL19; OMA:CCL19 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 34,689,570 bp[1] End 34,691,276 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 Start 42,070,757 bp[2] End 42,072,779 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix lymph node gallbladder thymus rectum mucosa of transverse colon mucosa of ileum left coronary artery olfactory zone of nasal mucosa epithelium of nasopharynx Top expressed in spleen adrenal gland muscle of thigh superior frontal gyrus thymus primary visual cortex dentate gyrus of hippocampal formation granule cell lip zone of skin right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function CCR10 chemokine receptor binding cytokine activity chemokine receptor binding CCR7 chemokine receptor binding chemokine activity CCR chemokine receptor binding protein binding Cellular component extracellular region intracellular anatomical structure extracellular space Biological process release of sequestered calcium ion into cytosol positive regulation of receptor-mediated endocytosis positive regulation of protein kinase B signaling positive regulation of cell motility positive regulation of dendritic cell dendrite assembly positive regulation of interleukin-12 production regulation of cell projection assembly monocyte chemotaxis positive regulation of T-helper 1 cell differentiation chemokine-mediated signaling pathway response to nitric oxide cellular response to tumor necrosis factor T cell costimulation response to virus cellular calcium ion homeostasis cell maturation myeloid dendritic cell chemotaxis positive regulation of JNK cascade dendritic cell chemotaxis positive regulation of phosphatidylinositol 3-kinase activity chemotaxis cell communication positive regulation of endocytosis positive regulation of GTPase activity response to prostaglandin E positive regulation of dendritic cell antigen processing and presentation positive regulation of chemotaxis cellular response to interleukin-1 positive regulation of T cell proliferation immune response positive regulation of ERK1 and ERK2 cascade establishment of T cell polarity positive regulation of glycoprotein biosynthetic process cellular response to interferon-gamma positive regulation of tumor necrosis factor production positive regulation of I-kappaB kinase/NF-kappaB signaling lymphocyte chemotaxis positive regulation of neutrophil chemotaxis inflammatory response immunological synapse formation mature conventional dendritic cell differentiation positive regulation of protein kinase activity antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway negative regulation of dendritic cell apoptotic process cytokine-mediated signaling pathway positive regulation of NIK/NF-kappaB signaling neutrophil chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6363 100861647 Ensembl ENSG00000172724 ENSMUSG00000118633 UniProt Q99731 n/a RefSeq (mRNA) NM_006274 XM_006538413 RefSeq (protein) NP_006265 n/a Location (UCSC) Chr 9: 34.69 – 34.69 Mb Chr 4: 42.07 – 42.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.^[6]

Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.^[7] The gene for CCL19 is located on human chromosome 9.^[8] This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7.^[7] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,^[9][10] CCR7+ central-memory T-Cells.^[11]