CCL8

Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.^[3][4]

CCL8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1ESR
Identifiers
Aliases	CCL8, HC14, MCP-2, MCP2, SCYA10, SCYA8, C-C motif chemokine ligand 8
External IDs	OMIM: 602283; HomoloGene: 48362; GeneCards: CCL8; OMA:CCL8 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 34,319,435 bp[1] End 34,321,402 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle buccal mucosa cell vena cava parietal pleura mucosa of transverse colon epithelium of colon decidua rectum lactiferous duct superficial temporal artery n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase activity cytokine activity heparin binding phospholipase activator activity CCR chemokine receptor binding chemokine activity protein binding CCR2 chemokine receptor binding Cellular component extracellular region extracellular space Biological process G protein-coupled receptor signaling pathway monocyte chemotaxis chemokine-mediated signaling pathway cellular response to tumor necrosis factor cell-cell signaling response to virus cellular calcium ion homeostasis neutrophil chemotaxis chemotaxis positive regulation of GTPase activity cellular response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma lymphocyte chemotaxis inflammatory response calcium ion transport signal transduction exocytosis protein phosphorylation antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of leukocyte migration negative regulation of leukocyte proliferation regulation of signaling receptor activity angiogenesis eosinophil chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6355 n/a Ensembl ENSG00000108700 n/a UniProt P80075 n/a RefSeq (mRNA) NM_005623 n/a RefSeq (protein) NP_005614 n/a Location (UCSC) Chr 17: 34.32 – 34.32 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans.^[4][5] MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response.^[6][7] CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.^[7][8]

CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1.^[9] In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes.^[10] CCL8 is also involved in attracting macrophages to the decidua in labor.^[11]