CCNB1IP1

E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.^[5][6]

CCNB1IP1
Identifiers
Aliases	CCNB1IP1, C14orf18, HEI10, cyclin B1 interacting protein 1
External IDs	OMIM: 608249; MGI: 2685134; HomoloGene: 18819; GeneCards: CCNB1IP1; OMA:CCNB1IP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,311,368 bp[1] End 20,333,312 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 51,026,705 bp[2] End 51,045,189 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary ganglionic eminence right ovary gastric mucosa cartilage tissue ventricular zone body of uterus apex of heart right auricle of heart left ventricle Top expressed in epiblast fetal liver hematopoietic progenitor cell embryo morula spermatocyte primitive streak embryo blastocyst otic placode primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding ubiquitin protein ligase activity transferase activity Cellular component condensed nuclear chromosome synaptonemal complex nucleus chromosome Biological process reciprocal meiotic recombination chiasma assembly meiosis blastocyst formation protein ubiquitination spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57820 239083 Ensembl ENSG00000100814 ENSMUSG00000071470 UniProt Q9NPC3 D3Z3K2 RefSeq (mRNA) NM_182852 NM_021178 NM_182849 NM_182851 NM_001111119 RefSeq (protein) NP_067001 NP_878269 NP_878272 NP_001104589 Location (UCSC) Chr 14: 20.31 – 20.33 Mb Chr 14: 51.03 – 51.05 Mb PubMed search [3] [4]
Wikidata
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HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM]^[6] It is considered a housekeeping gene.

During meiosis, crossing over between homologous chromosomes (homologs) facilitates accurate chromosome segregation.^[7] In mammals, the ring-domain protein CCNB1IP1, also known as HEI10, promotes crossing over between each pair of homologs during meiosis.^[7] Studies in the mouse showed that this pro-crossover ring-domain protein facilitates the homologous recombination and DNA repair processes that produce crossovers.^[7]