CCNG2

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.^[5][6]

CCNG2
Identifiers
Aliases	CCNG2, cyclin G2
External IDs	OMIM: 603203; MGI: 1095734; HomoloGene: 3208; GeneCards: CCNG2; OMA:CCNG2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 77,157,207 bp[1] End 77,433,388 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 93,415,116 bp[2] End 93,424,090 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid germinal epithelium parietal pleura tibia visceral pleura oral cavity cerebellar vermis epithelium of nasopharynx Brodmann area 23 lactiferous duct Top expressed in medial ganglionic eminence saccule left colon jejunum thymus decidua superior cervical ganglion otic vesicle ileum dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding Cellular component cytoplasm cyclin-dependent protein kinase holoenzyme complex nucleus Biological process cell cycle regulation of cell cycle cell division regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle protein phosphorylation regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 901 12452 Ensembl ENSG00000138764 ENSMUSG00000029385 UniProt Q16589 O08918 RefSeq (mRNA) NM_004354 NM_007635 RefSeq (protein) NP_004345 NP_031661 Location (UCSC) Chr 4: 77.16 – 77.43 Mb Chr 5: 93.42 – 93.42 Mb PubMed search [3] [4]
Wikidata
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Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.^[6]

Interactions

CCNG2 has been shown to interact with PPP2CA.^[7]