Cyclin T2

Cyclin-T2 is a protein that in humans is encoded by the CCNT2 gene.^[5][6][7]

CCNT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IVX
Identifiers
Aliases	CCNT2, CYCT2, cyclin T2
External IDs	OMIM: 603862; MGI: 1920199; HomoloGene: 14043; GeneCards: CCNT2; OMA:CCNT2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q21.3 Start 134,918,235 bp[1] End 134,959,342 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E3 Start 127,701,901 bp[2] End 127,735,798 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon body of pancreas visceral pleura endothelial cell testicle monocyte Brodmann area 23 rectum germinal epithelium endometrium Top expressed in medullary collecting duct Rostral migratory stream renal corpuscle substantia nigra aortic valve zygote secondary oocyte ascending aorta retinal pigment epithelium mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding 7SK snRNA binding transcription coactivator binding cyclin-dependent protein serine/threonine kinase regulator activity RNA polymerase binding protein binding protein serine/threonine kinase activity chromatin binding cyclin-dependent protein serine/threonine kinase activator activity Cellular component cyclin/CDK positive transcription elongation factor complex nucleus perinuclear region of cytoplasm cytoplasm nucleoplasm cytosol plasma membrane cyclin-dependent protein kinase holoenzyme complex Biological process regulation of muscle cell differentiation early viral transcription positive regulation of phosphorylation of RNA polymerase II C-terminal domain cell cycle late viral transcription cell division regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II viral process transcription, DNA-templated snRNA transcription by RNA polymerase II protein phosphorylation skeletal muscle tissue development regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription, elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 905 72949 Ensembl ENSG00000082258 ENSMUSG00000026349 UniProt O60583 Q7TQK0 RefSeq (mRNA) NM_001241 NM_058241 NM_001320748 NM_001320749 NM_028399 RefSeq (protein) NP_001232 NP_001307677 NP_001307678 NP_490595 NP_082675 Location (UCSC) Chr 2: 134.92 – 134.96 Mb Chr 1: 127.7 – 127.74 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described.^[7]

Interactions

Cyclin T2 has been shown to interact with CDK9^[5] and Retinoblastoma protein.^[8]