Cyclin T1

Cyclin-T1 is a protein that in humans is encoded by the CCNT1 gene.^[5][6]

CCNT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PK2, 3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCI, 4BCJ, 4EC8, 4EC9, 4IMY, 4OGR, 4OR5
Identifiers
Aliases	CCNT1, CCNT, CYCT1, HIVE1, cyclin T1
External IDs	OMIM: 143055; MGI: 1328363; HomoloGene: 947; GeneCards: CCNT1; OMA:CCNT1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.11-q13.12 Start 48,688,458 bp[1] End 48,716,998 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 98,436,570 bp[2] End 98,468,804 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm superior surface of tongue renal medulla pylorus tail of epididymis lactiferous duct caput epididymis nipple mucosa of paranasal sinus pericardium Top expressed in Rostral migratory stream genital tubercle conjunctival fornix morula neural layer of retina ganglionic eminence granulocyte zygote lacrimal gland embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding snRNA binding chromatin binding 7SK snRNA binding cyclin-dependent protein serine/threonine kinase regulator activity protein binding RNA polymerase binding transcription factor binding protein serine/threonine kinase activity protein kinase binding cyclin-dependent protein serine/threonine kinase activator activity Cellular component nucleoplasm nucleolus cyclin/CDK positive transcription elongation factor complex nucleus cyclin-dependent protein kinase holoenzyme complex Biological process regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of mRNA polyadenylation regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter transcription by RNA polymerase II cell division protein phosphorylation positive regulation of phosphorylation of RNA polymerase II C-terminal domain positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of viral transcription cell cycle positive regulation of transcription by RNA polymerase II viral process transcription, DNA-templated snRNA transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription, elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 904 12455 Ensembl ENSG00000129315 ENSMUSG00000011960 UniProt O60563 Q9QWV9 RefSeq (mRNA) NM_001240 NM_001277842 NM_009833 NM_001368702 RefSeq (protein) NP_001231 NP_001264771 NP_033963 NP_001355631 Location (UCSC) Chr 12: 48.69 – 48.72 Mb Chr 15: 98.44 – 98.47 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.^[7]

Interactions

Cyclin T1 has been shown to interact with the following:

• Aryl hydrocarbon receptor^[8]
• CDK9^{[6][9][10][11][12][13][14][15][16]}
• Granulin^[10]
• HEXIM1^[9]
• Myc^[17]
• NUFIP1^[11]
• Promyelocytic leukemia protein^[18]

See also

• Cyclin T2