CCP110

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication.^[5][6] CP110 suppresses a cilia assembly program.^[7]

CCP110
Identifiers
Aliases	CCP110, CP110, Cep110, centriolar coiled-coil protein 110kDa, centriolar coiled-coil protein 110
External IDs	OMIM: 609544; MGI: 2141942; HomoloGene: 8810; GeneCards: CCP110; OMA:CCP110 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.3 Start 19,523,811 bp[1] End 19,553,408 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 118,311,775 bp[2] End 118,336,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve corpus callosum globus pallidus internal globus pallidus external globus pallidus buccal mucosa cell bronchial epithelial cell inferior ganglion of vagus nerve pars reticulata subthalamic nucleus Top expressed in superior cervical ganglion olfactory epithelium zygote hand spermatocyte seminiferous tubule secondary oocyte lateral geniculate nucleus globus pallidus tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cell projection cytosol centriole cytoplasm centrosome cilium microtubule organizing center cytoskeleton protein-containing complex Biological process cell projection organization G2/M transition of mitotic cell cycle negative regulation of cilium assembly centriole replication positive regulation of cilium assembly ciliary basal body organization centrosome duplication regulation of cytokinesis protein deubiquitination ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9738 101565 Ensembl ENSG00000103540 ENSMUSG00000033904 UniProt O43303 Q7TSH4 RefSeq (mRNA) NM_001199022 NM_014711 NM_001323569 NM_001323570 NM_001323571 NM_001323572 NM_001323576 NM_001323577 NM_182995 NM_001360793 NM_001360794 RefSeq (protein) NP_001185951 NP_001310498 NP_001310499 NP_001310500 NP_001310501 NP_001310505 NP_001310506 NP_055526 NP_892040 NP_001347722 NP_001347723 Location (UCSC) Chr 16: 19.52 – 19.55 Mb Chr 7: 118.31 – 118.34 Mb PubMed search [3] [4]
Wikidata
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