CCRL2

C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.^[5][6] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.^[7]

CCRL2
Identifiers
Aliases	CCRL2, ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR, C-C motif chemokine receptor like 2
External IDs	OMIM: 608379; MGI: 1920904; HomoloGene: 2948; GeneCards: CCRL2; OMA:CCRL2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 46,407,166 bp[1] End 46,412,997 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F2|9 60.92 cM Start 110,883,554 bp[2] End 110,886,587 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum upper lobe of left lung mucosa of sigmoid colon appendix monocyte right lung granulocyte spleen bone marrow cells Top expressed in granulocyte right lung lobe embryo muscle of thigh stroma of bone marrow triceps brachii muscle vastus lateralis muscle digastric muscle left lung temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity chemokine receptor activity signal transducer activity CCR chemokine receptor binding chemokine receptor binding C-C chemokine receptor activity chemokine binding C-C chemokine binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane cytoplasm external side of plasma membrane Biological process chemotaxis G protein-coupled receptor signaling pathway signal transduction chemokine-mediated signaling pathway inflammatory response immune response positive regulation of cytosolic calcium ion concentration calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9034 54199 Ensembl ENSG00000121797 ENSMUSG00000043953 UniProt O00421 O35457 RefSeq (mRNA) NM_001130910 NM_003965 NM_017466 NM_001302376 NM_001302377 RefSeq (protein) NP_001124382 NP_003956 NP_001289305 NP_001289306 NP_059494 Location (UCSC) Chr 3: 46.41 – 46.41 Mb Chr 9: 110.88 – 110.89 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.^[6]