Interleukin 1 receptor, type I

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.^[5]

IL1R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G0Y, 1IRA, 1ITB, 4DEP, 4GAF
Identifiers
Aliases	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1
External IDs	OMIM: 147810; MGI: 96545; HomoloGene: 677; GeneCards: IL1R1; OMA:IL1R1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2-q12.1 Start 102,064,544 bp[1] End 102,179,874 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 B|1 18.81 cM Start 40,225,080 bp[2] End 40,317,257 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva tibia pericardium corpus epididymis decidua caput epididymis urethra vena cava visceral pleura parietal pleura Top expressed in islet of Langerhans seminal vesicula umbilical cord skin of external ear medullary collecting duct aortic valve primary oocyte ciliary body tunica media of zone of aorta cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1, type I, activating receptor activity signal transducer activity platelet-derived growth factor receptor binding protease binding protein binding transmembrane signaling receptor activity interleukin-1 receptor activity interleukin-1 binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region cell surface external side of plasma membrane Biological process cell surface receptor signaling pathway immune response regulation of inflammatory response signal transduction positive regulation of interleukin-1-mediated signaling pathway positive regulation of neutrophil extravasation response to interleukin-1 cytokine-mediated signaling pathway interleukin-1-mediated signaling pathway positive regulation of interferon-gamma production positive regulation of T-helper 1 cell cytokine production inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3554 16177 Ensembl ENSG00000115594 ENSMUSG00000026072 UniProt P14778 P13504 RefSeq (mRNA) NM_000877 NM_001288706 NM_001320978 NM_001320980 NM_001320981 NM_001320982 NM_001320983 NM_001320984 NM_001320985 NM_001320986 NM_001123382 NM_008362 RefSeq (protein) NP_000868 NP_001275635 NP_001307907 NP_001307909 NP_001307910 NP_001307911 NP_001307912 NP_001307913 NP_001307914 NP_001307915 NP_001116854 NP_032388 Location (UCSC) Chr 2: 102.06 – 102.18 Mb Chr 1: 40.23 – 40.32 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.^[5]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1,^[6] Myd88^[7][8] and IL1RAP.^[9]

See also

• Cluster of differentiation
• Interleukin 1 receptor, type II