CD151

CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.^[5]

CD151
Identifiers
Aliases	CD151, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24, CD151 molecule (Raph blood group), EBS7
External IDs	OMIM: 602243; MGI: 1096360; HomoloGene: 20916; GeneCards: CD151; OMA:CD151 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 832,887 bp[1] End 839,831 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 86.82 cM Start 141,047,305 bp[2] End 141,051,386 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta right coronary artery left coronary artery popliteal artery tibial arteries stromal cell of endometrium apex of heart body of pancreas upper lobe of left lung Top expressed in endothelial cell of lymphatic vessel medullary collecting duct Paneth cell renal corpuscle iris tunica media of zone of aorta carotid body tunica adventitia of aorta ciliary body decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding protein binding Cellular component cytosol membrane focal adhesion basement membrane integral component of membrane integral component of plasma membrane plasma membrane cell surface Biological process cell adhesion cell surface receptor signaling pathway hemidesmosome assembly T cell proliferation cell migration positive regulation of cell migration wound healing, spreading of cells positive regulation of endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 977 12476 Ensembl ENSG00000177697 ENSMUSG00000025510 UniProt P48509 Q6ZNZ0 O35566 RefSeq (mRNA) NM_139030 NM_001039490 NM_004357 NM_139029 NM_001111049 NM_001111050 NM_009842 RefSeq (protein) NP_001034579 NP_004348 NP_620598 NP_620599 NP_001034579.1 NP_004348.2 NP_620598.1 NP_620599.1 NP_001104519 NP_001104520 NP_033972 Location (UCSC) Chr 11: 0.83 – 0.84 Mb Chr 7: 141.05 – 141.05 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.^[5] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.^[6][7]

Interactions

Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.^[8]

See also

• Cluster of differentiation
• Tetraspanin