CD180

CD180 antigen is a protein that in humans is encoded by the CD180 gene.^[5][6][7][8]

CD180
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B2D
Identifiers
Aliases	CD180, LY64, Ly78, RP105, CD180 molecule
External IDs	OMIM: 602226; MGI: 1194924; HomoloGene: 4077; GeneCards: CD180; OMA:CD180 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q12.3 Start 67,179,613 bp[1] End 67,196,799 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 102,830,066 bp[2] End 102,876,137 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell lymph node white blood cell monocyte granulocyte spleen appendix bone marrow cell blood superficial temporal artery Top expressed in mesenteric lymph nodes zygote granulocyte secondary oocyte spleen primary oocyte right ventricle tibiofemoral joint blood thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane extracellular space extracellular matrix Biological process positive regulation of lipopolysaccharide-mediated signaling pathway innate immune response cellular response to lipopolysaccharide B cell proliferation involved in immune response immune system process toll-like receptor signaling pathway inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4064 17079 Ensembl ENSG00000134061 ENSMUSG00000021624 UniProt Q99467 Q62192 RefSeq (mRNA) NM_005582 NM_008533 NM_001360519 RefSeq (protein) NP_005573 NP_032559 NP_001347448 Location (UCSC) Chr 5: 67.18 – 67.2 Mb Chr 13: 102.83 – 102.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.^[7]

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.^[9][10]