CCR3 (gene)

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.^[5]

CCR3
Identifiers
Aliases	CCR3, CC-CKR-3, CD193, CKR3, CMKBR3, C-C motif chemokine receptor 3, CKR 3, C C CKR3
External IDs	OMIM: 601268; MGI: 104616; HomoloGene: 20436; GeneCards: CCR3; OMA:CCR3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 46,130,890 bp[1] End 46,266,706 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F4|9 75.05 cM Start 123,822,009 bp[2] End 123,831,726 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte blood muscle of thigh monocyte gallbladder appendix gonad muscle of arm biceps brachii granulocyte Top expressed in embryo spleen granulocyte zygote intestinal villus bone marrow Ileal epithelium secondary oocyte blood cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein binding C-C chemokine receptor activity chemokine receptor activity C-C chemokine binding chemokine binding Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane cytoplasm external side of plasma membrane Biological process positive regulation of endothelial cell proliferation adenylate cyclase-modulating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration chemokine-mediated signaling pathway positive regulation of angiogenesis chemotaxis cellular defense response cell adhesion inflammatory response viral process signal transduction G protein-coupled receptor signaling pathway immune response calcium-mediated signaling cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1232 12771 Ensembl ENSG00000183625 ENSMUSG00000035448 UniProt P51677 P51678 RefSeq (mRNA) NM_001164680 NM_001837 NM_178328 NM_178329 NM_009914 RefSeq (protein) NP_001158152 NP_001828 NP_847898 NP_847899 NP_034044 Location (UCSC) Chr 3: 46.13 – 46.27 Mb Chr 9: 123.82 – 123.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CCR3 has also recently been designated CD193 (cluster of differentiation 193).

Function

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils,^[6] and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1, enabling viral infection in cells that also express CD4, the receptor of HIV-1.^[7] This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.^[5]

See also

• Cluster of differentiation

Interactions

CCR3 (gene) has been shown to interact with CCL5.^[8][9][10]