CD2

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,^[5] LFA-3 receptor, erythrocyte receptor and rosette receptor.^[6]

CD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Identifiers
Aliases	CD2, LFA-2, SRBC, T11, CD2 molecule
External IDs	OMIM: 186990; MGI: 88320; HomoloGene: 1338; GeneCards: CD2; OMA:CD2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1 Start 116,754,430 bp[1] End 116,769,229 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 44.17 cM Start 101,183,215 bp[2] End 101,195,255 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte thymus lymph node testicle appendix blood epithelium of nasopharynx superficial temporal artery spleen mucosa of ileum Top expressed in thymus mesenteric lymph nodes spleen blood right lung lobe subcutaneous adipose tissue embryo ankle joint embryo granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding signaling receptor binding signaling receptor activity antigen binding protein kinase binding receptor tyrosine kinase binding protein self-association Cellular component integral component of membrane membrane cell-cell junction anchored component of plasma membrane integral component of plasma membrane extracellular region cell surface cytoplasmic side of plasma membrane external side of plasma membrane plasma membrane protein-containing complex membrane raft Biological process positive regulation of myeloid dendritic cell activation heterotypic cell-cell adhesion natural killer cell activation membrane raft polarization cell surface receptor signaling pathway cell adhesion positive regulation of tumor necrosis factor production T cell activation leukocyte migration regulation of T cell differentiation apoptotic process cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 914 12481 Ensembl ENSG00000116824 ENSMUSG00000027863 UniProt P06729 Q53F96 P08920 RefSeq (mRNA) NM_001767 NM_001328609 NM_013486 RefSeq (protein) NP_001315538 NP_001758 NP_001758.2 NP_038514 Location (UCSC) Chr 1: 116.75 – 116.77 Mb Chr 3: 101.18 – 101.2 Mb PubMed search [3] [4]
Wikidata
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This article is about a molecule in immunology and is not to be confused with CD₂, the simplified chemical formula of deuterated polyethylene.

Function

It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.^[7]

In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.^[8]

Diagnostic relevance

CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.^[9]

Classification

Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.^[8]

Interactions

CD2 has been shown to interact with CD2BP2,^[10] Lck^[11] and PSTPIP1.^[12]