CD200R1

Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.^[5][6][7] CD200R1 is expressed on the surface of myeloid cells^[8] and CD4+ T cells.^[9] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,^[10] epithelial cells,^[11] endothelial cells,^[12] fibroblasts,^[13] and lymphoid cells.^[14]

CD200R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BFG, 4BFI
Identifiers
Aliases	CD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
External IDs	OMIM: 607546; MGI: 1889024; HomoloGene: 10957; GeneCards: CD200R1; OMA:CD200R1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.2 Start 112,921,205 bp[1] End 112,975,103 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B4 Start 44,586,099 bp[2] End 44,615,341 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle epithelium of nasopharynx nasal epithelium bone marrow cell granulocyte monocyte lymph node appendix spleen gallbladder Top expressed in granulocyte stroma of bone marrow calvaria pharynx right lobe of liver embryo lumbar spinal ganglion dermis blood spleen More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding immunoglobulin receptor activity signaling receptor activity glycosylated region protein binding Cellular component integral component of membrane extracellular region receptor complex membrane external side of plasma membrane plasma membrane cell surface Biological process viral process regulation of immune response signal transduction heterotypic cell-cell adhesion intracellular signal transduction Fc receptor signaling pathway regulation of neuroinflammatory response negative regulation of neuroinflammatory response negative regulation of neuron death negative regulation of macrophage migration negative regulation of T cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131450 57781 Ensembl ENSG00000163606 ENSMUSG00000022667 UniProt Q8TD46 Q9ES57 RefSeq (mRNA) NM_138806 NM_138939 NM_138940 NM_170780 NM_021325 RefSeq (protein) NP_620161 NP_620385 NP_620386 NP_740750 NP_067300 Location (UCSC) Chr 3: 112.92 – 112.98 Mb Chr 16: 44.59 – 44.62 Mb PubMed search [3] [4]
Wikidata
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CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),^[15] interferons, and inducible nitric oxide synthase (iNOS).^[16]

Function

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.^[7]