TEK tyrosine kinase

Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene.^[5][6] Also known as TIE2, it is an angiopoietin receptor.

TEK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4K0V, 1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3L8P, 4X3J
Identifiers
Aliases	TEK, CD202B, TIE-2, TIE2, VMCM, VMCM1, TEK tyrosine kinase, TEK receptor tyrosine kinase, GLC3E
External IDs	OMIM: 600221; MGI: 98664; HomoloGene: 397; GeneCards: TEK; OMA:TEK - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.2 Start 27,109,141 bp[1] End 27,230,174 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C5|4 43.34 cM Start 94,627,526 bp[2] End 94,763,213 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung visceral pleura upper lobe of left lung oocyte parietal pleura secondary oocyte lower lobe of lung subcutaneous adipose tissue metanephric glomerulus placenta Top expressed in Vasculature of brain right lung right lung lobe left lung atrium left lung lobe atrioventricular valve semi-lunar valve aortic valve endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding signaling receptor activity growth factor binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component cytoplasm integral component of membrane membrane cell-cell junction focal adhesion integral component of plasma membrane stress fiber extracellular region microvillus cell surface basal plasma membrane cell junction basolateral plasma membrane apical plasma membrane actin filament membrane raft cytoskeleton microtubule organizing center plasma membrane receptor complex Biological process negative regulation of endothelial cell apoptotic process positive regulation of protein kinase B signaling positive regulation of protein phosphorylation response to hypoxia positive regulation of endothelial cell proliferation heart trabecula formation phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway regulation of endothelial cell apoptotic process cell-cell signaling response to peptide hormone sprouting angiogenesis negative regulation of apoptotic process endochondral ossification positive regulation of intracellular signal transduction response to organic substance positive regulation of angiogenesis MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity positive regulation of endothelial cell migration response to estrogen heart development regulation of vascular permeability protein phosphorylation protein complex oligomerization endothelial cell proliferation angiogenesis Tie signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of angiogenesis protein autophosphorylation positive regulation of focal adhesion assembly regulation of establishment or maintenance of cell polarity positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation substrate adhesion-dependent cell spreading response to cAMP definitive hemopoiesis positive regulation of actin cytoskeleton reorganization negative regulation of inflammatory response leukocyte migration signal transduction glomerulus vasculature development negative regulation of signal transduction cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7010 21687 Ensembl ENSG00000120156 ENSMUSG00000006386 UniProt Q02763 Q02858 RefSeq (mRNA) NM_000459 NM_001290077 NM_001290078 NM_001375475 NM_001375476 NM_001290549 NM_001290551 NM_013690 RefSeq (protein) NP_000450 NP_001277006 NP_001277007 NP_001362404 NP_001362405 NP_001277478 NP_001277480 NP_038718 Location (UCSC) Chr 9: 27.11 – 27.23 Mb Chr 4: 94.63 – 94.76 Mb PubMed search [3] [4]
Wikidata
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Function

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase.)^[7]

This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats.^[8] The ligand for the receptor is angiopoietin-1.^[7] TEK has also been suggested as a marker for nucleus pulposus progenitor cells, from the intervertebral disc, which upon activation by Angiopoietin-1 starts to multiply and differentiate.^[9][10]

Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.^[7]

In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.^[11]

Interactions

TEK tyrosine kinase has been shown to interact with:

• ANGPT2,^[8][12][13]
• Angiopoietin 1,^{[8][12][13][14]}
• DOK2.^[15][16]

See also

• Tie-2/Ang-1 signaling